This is good article to collect the BLE issues I actually met from iOS5 to iOS6 upgrading.
The main issues are listed here:
1. The app crashed in the CFUUIDCreateString routing and that the UUID property of the peripheral was NULL.
2. The peripheral will not be disconnect immediately when App disconnect BLE link.
Refer to here for more details:
http://see.sl088.com/wiki/CC2540_IOS6